Oricent provides customized in-silico services to our global partners by keeping in consideration of Intellectual property of a client/company. We ensure our clients with deliverables of highest quality and accuracy on time.
Each research is designed and customized according to client in order to satisfy all requirements.
TARGET DISCOVERY
Our company main focus lies in Target Discovery involving
Disease Target area
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Genome data management
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Development of Computational network of genes & proteins
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Selection of probable targets
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Designing the sequence database of all potential Targets from different sources
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Modeling the 3D structure of protein
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Active site prediction of these modeled structures
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Qualitative Physico Chemical Analysis of these whole systems and active sites |
LEAD MOLECULE SCREENING
Screening from million+ compound databases against the target protein molecule
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Best hits for protein targets (Energy Binding calculations)
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Designing a database of potential complementary chemicals for each target.
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All molecules in database are ranked on the basis of new scoring function.
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Help user in designing new lead molecule for novel or existing targets. |
DATA ANALYSIS
Microarray data analysis @ Oricent aims at:
Basic Analysis:
- Normalization – Best suited to platform
- Quality control of Sample
- Quality control on probes
- Statistical analysis according to the experimental design
- Multiple testing correction
- Fold change analysis >= 2 fold up and down
- Clustering for gene of interest
- Principle component analysis
- Similar gene locations with reference to pattern of gene of interest
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Advanced Data Analysis:
- Gene ontology analysis for gene of interest (GO analysis)
- Gene set enrichment analysis (GSEA)
- Finding significant pathways, on availability of pathways for that particular organism
- Pathway analysis on curated pathway database
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CUSTOMIZED SOFTWARE & DATABASE DEVELOPMENT
Product development at Oricent is heavily focused on developing customized bioinformatics software. This software is specially designed for addressing the management and analysis of data towards personalized medicines, drug discovery and Microarray data analysis, Knowledge centre software for scientific solutions.
Mining Databases:
Pharmaceutical research for a single drug includes thousands of pages and numerous publications. We develop friendly navigational databases for literature mining for company’s which includes database of molecules, pathways, disease research repository and patents involved and granted in research. Our database design helps scientist to target research in a specific manner using best-of-quality research literature.
Biological Databases:
We develop customized target centric/Disease specific databases for genomics and proteomics study involving complete repository and functionality analysis. Navigation involves complete annotations as well as accessing link to data bank repositories. Client can design research in own customized way of designing pathways and network analysis.
For each selected target, complete functionality and networking is design in such a way that scientist will understand activity in easy manner. Automated curation from publications repository will be listed for every selected target.
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